Sympathetic Nerve Activation Drives Cardiac Fibrosis and Arrhythmia in Lean Metabolic Dysfunction‐Associated Steatohepatitis Mice Concurrently Exposed to Ethanol and a High‐Fat/High‐Cholesterol Diet

Sympathetic nerve-associated activation of macrophages and fibroblast-like stromal cells is linked to myocardial fibrosis and increased arrhythmia susceptibility in lean MASH. Even modest ethanol intake appears to accelerate disease progression and heighten arrhythmia risk when combined with a high-fat/high-cholesterol diet. These findings suggest that targeting sympathetic activation and inflammation may represent a potential therapeutic strategy for cardiovascular prevention in lean MASH.