A Meta-Analysis Comparing Two Disinfectants for Digestive Endoscope Disinfection

ObjectiveThis meta-analysis aimed to systematically compare the disinfection efficacy of Peracetic Acid (PAA) and Phthalaldehyde (OPA) for digestive endoscopes.MethodsRandomized controlled trials (RCTs) comparing PAA and OPA for digestive endoscope disinfection were independently identified by two investigators through systematic searches of databases, including Wanfang Data, China National Knowledge Infrastructure (CNKI), VIP Database, Chinese Biomedical Database (CBM), PubMed, Cochrane Library, Web of Science, and Embase. Study selection, data extraction, and quality assessment of included studies were also performed by them independently. A meta-analysis was conducted using RevMan 5.4 software on studies that met the predefined quality criteria.ResultsSeven RCTs involving a total of 1038 digestive endoscope procedures were included. The meta-analysis demonstrated a significantly higher disinfection qualification rate for PAA compared to OPA (OR=2.31, 95% CI: 1.04-5.12, P=0.04). No statistically significant differences were found between the two disinfectants regarding post-disinfection bacterial colony counts or associated disinfection costs (P>0.05 for both).ConclusionImmersion in PAA provides superior disinfection efficacy for digestive endoscopes compared to OPA.