Integrated metabolomics and genetic analyses reveal loss of protective docosahexaenoic acid as a key driver linking ultra-processed food to Crohn’s disease risk
The adverse effects of UPF on CD risk may be driven by a relative deficiency of protective metabolites such as DHA, apart from additive harm to metabolic depletion. This reframes UPF-related risk and highlighting potential targets for precision nutrition in CD prevention.
Authors
- Evropi Τheodoratou (ORCID: https://orcid.org/0000-0001-5887-9132)
- Yuhao Sun (ORCID: https://orcid.org/0000-0001-6987-3721)
- Xixian Ruan (ORCID: https://orcid.org/0000-0002-4937-9168)
- Lintao Dan (ORCID: https://orcid.org/0000-0001-5963-2772)
- Judith Wellens (ORCID: https://orcid.org/0000-0002-1647-8151)
- Xue Li (ORCID: https://orcid.org/0000-0002-8633-6087)
- J Yao
- R Kalla
- J Chen
- F Magro
- J Satsangi
- L Tian
- S Wang
- Shuai Yuan
- Jonas F Ludvigsson
Institutions
- Uppsala University (SE)
- Central South University (CN)
- Inserm (FR)
- Universidade do Porto (PT)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Edinburgh Cancer Research (GB)
- John Radcliffe Hospital (GB)
- Karolinska Institutet (SE)
- Örebro University Hospital (SE)
- Philadelphia VA Medical Center (US)
- Centre for Health Technology and Services Research (PT)
- Centre for Inflammation Research (GB)
- Third Xiangya Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Institute of Genetics and Cancer (GB)
- Nutrition-Génétique et Exposition aux Risques Environnementaux (FR)
- University of Pennsylvania (US)
- Université de Lorraine (FR)
- Medical Research Council (GB)
- University of Edinburgh (GB)
- KU Leuven (BE)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-22
- DOI
- https://doi.org/10.64898/2026.02.20.26346727
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00