Prompting is All You Need: How to Make LLMs More Helpful for Clinical Decision Support

Structured prompting substantially enhances LLM performance for acute stroke thrombolysis CDS. Notably, some models, including the proprietary GPT-4o and o3, and the open-source reasoning model r1-1776, achieved excellent safety and adherence with structured prompts. For clinical deployment of any LLM, structured prompts are crucial, and vigilant human oversight remains essential.