Integrating scRNA-seq and snRNA-seq with spatial transcriptomics to unlock the xylem puzzle

Our findings demonstrate the high compatibility and complementarity of scRNA-seq and snRNA-seq platforms. This integrated approach not only overcomes key limitations of individual technologies but also provides a practical and scalable framework for resolving complex developmental trajectories in plants. It successfully reconstructs the full continuum of xylem development, from cambial progenitors through secondary cell wall formation and to programmed cell death.

Authors

Institutions

Publication Details

Journal
Genome biology
Published
2026-02-23
DOI
https://doi.org/10.1186/s13059-026-04007-z
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Integrating scRNA-seq and snRNA-seq with spatial transcriptomics to unlock the xylem puzzle

Ying‐Chung Jimmy Lin, Botong Tong, Quanzi Li, Jo-Wei Allison Hsieh et al.
Genome biology
Single-cell and spatial transcriptomics
article

Integrating scRNA-seq and snRNA-seq with spatial transcriptomics to unlock the xylem puzzle

Ying‐Chung Jimmy Lin, Botong Tong, Quanzi Li, Jo-Wei Allison Hsieh, Hui Li, Jr-Fong Dang, Mingke Wei, Ronald Sederoff
article en

Abstract

Our findings demonstrate the high compatibility and complementarity of scRNA-seq and snRNA-seq platforms. This integrated approach not only overcomes key limitations of individual technologies but also provides a practical and scalable framework for resolving complex developmental trajectories in plants. It successfully reconstructs the full continuum of xylem development, from cambial progenitors through secondary cell wall formation and to programmed cell death.

Genome biology
Inner Mongolia Agricultural University (CN), Zhejiang A & F University (CN), North Carolina State University (US), National Taiwan University of Science and Technology (TW), National Taiwan University (TW), Heilongjiang Provincial Academy of Agricultural Sciences (CN), Zhejiang Academy of Forestry (CN), University of California, Davis (US), National Cheng Kung University (TW)
Openalex Percentile: Top 46%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Integrating scRNA-seq and snRNA-seq with spatial transcriptomics to unlock the xylem puzzle — Ying‐Chung Jimmy Lin, Botong Tong, et al. · Genome biology (2026) | TGRS Research Map | TGRS