Developmental Differences in White Matter Microarchitecture in Youth with ADHD: Longitudinal Findings from the ABCD Study
ADHD was associated with reductions in isotropic diffusion in white matter tracts, and possibly with complementary reductions in directional diffusion of select tracts. Isotropic diffusion findings suggest atypical glial cellularity in white matter during late childhood.
Authors
- Katherine L. Bottenhorn (ORCID: https://orcid.org/0000-0002-7796-8795)
- Hamed Ahmadi (ORCID: https://orcid.org/0000-0003-1218-3775)
- Sarah L. Karalunas (ORCID: https://orcid.org/0000-0003-3082-7458)
- Bradley S Peterson
- L. Nate Overholtzer
Institutions
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- Florida International University (US)
- Keck Hospital of USC (US)
- Syracuse University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-21
- DOI
- https://doi.org/10.64898/2026.02.20.707054
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Drug Abuse