Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections

While ERG11 structural mutations are foundational, the elevated azole resistance in the C. albicans isolates of HIV-infected patients is associated with specific CDR1/CDR2 mutations and distinct ERG11 promoter variants, highlighting genomic features that warrant further functional validation.

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Publication Details

Journal
Journal of Biomedical Science
Published
2026-02-22
DOI
https://doi.org/10.1186/s12929-026-01231-4
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00

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article

Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections

I-An Tsai, Ching-Min Chang, J. J. Hsu, H Y Huang et al.
Journal of Biomedical Science
Antifungal resistance and susceptibility
article

Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections

I-An Tsai, Ching-Min Chang, J. J. Hsu, H Y Huang, Shih Ming Chu, C. Hsieh, Jang-Jih Lu, Ting-Wen Chen, Shao-Hung Wang, Ming-Horng Tsai
article en

Abstract

While ERG11 structural mutations are foundational, the elevated azole resistance in the C. albicans isolates of HIV-infected patients is associated with specific CDR1/CDR2 mutations and distinct ERG11 promoter variants, highlighting genomic features that warrant further functional validation.

Journal of Biomedical ScienceVol. 33(1)
National Yang Ming Chiao Tung University (TW), Chang Gung University (TW), National Chiayi University (TW), Chang Gung Memorial Hospital (TW), Taipei Tzu Chi Hospital (TW)
Chang Gung Medical Foundation, National Science and Technology Council
Good health and well-being
Openalex Percentile: Top 47%
Antifungal resistance and susceptibility
DOIOpen Access PDFOpenAlex
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