Time-dependent efficacy and safety of hypertonic saline versus mannitol in pediatric traumatic brain injury: a systematic review and meta-analysis
In pediatric TBI, hypertonic saline and mannitol provide comparable efficacy for ICP reduction and mortality, with HTS demonstrating rapid ICP lowering and manageable safety signals. While HTS is generally well tolerated, further high-quality multicenter RCTs with standardized protocols and long-term outcomes are needed to clarify its clinical advantages over mannitol.
Authors
- Ameer Hassoun (ORCID: https://orcid.org/0000-0003-4524-6664)
- Abdalla Mohamed Hadhoud (ORCID: https://orcid.org/0000-0002-1410-7680)
- Shree Rath
- Eslam Abady (ORCID: https://orcid.org/0009-0007-2087-3297)
- Eric Lusinski
- Yahya A Mahmoud
- Mohammed Alsabri
Institutions
- Al-Azhar University – Gaza (PS)
- Cornell University (US)
- Tanta University (EG)
- Altera (United States) (US)
- Presbyterian Hospital (US)
- St. Christopher's Hospital for Children (US)
- All India Institute of Medical Sciences (IN)
- Alexandria University (EG)
Publication Details
- Journal
- Brain Injury
- Published
- 2026-02-22
- DOI
- https://doi.org/10.1080/02699052.2026.2634095
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00