Discovery of secondary metabolites from the marine-derived fungus <i>Gamszarea microspora</i> BTBU20212050

Two novel metabolites, gamdione (<b>1)</b> and irpexidine C <b>(2</b>), along with six known compounds, including irpexidine A (<b>3</b>), (<i>E</i>)-3-methylpent-2-en-1,5-dioic acid (<b>4</b>), (<i>Z</i>)-3-methylpent-2-en-1,5-dioic acid (<b>5</b>), hydroxyphenylacetic acid (<b>6</b>), 1,3-dihydro-2<i>H</i>-indol-2-one (<b>7</b>) and lumichrome (<b>8</b>), were isolated from the marine-derived fungus <i>Gamszarea microspora</i> BTBU20212050. Their chemical structures were elucidated by comprehensive 1D/2D NMR and HRESIMS spectroscopic analysis, and comparison with spectral data reported in the existing literature. Antimicrobial activity assays showed that gamdione (<b>1</b>) displayed weak antifungal activity against <i>Candida albicans</i>.