The Response of Alpha‐Aminoadipic Acid (2‐AAA) to Short Term Lysine Ingestion in Healthy Individuals
Our data suggest that orally ingested lysine is catabolised to 2-AAA over several hours. However, lysine ingestion also stimulates an increase in 2-AAA from endogenous sources. The rate of production and excretion differs between individuals, suggestive of controlled regulation of this metabolic pathway. Individuals with a higher WHR, indicative of greater visceral adiposity, may have increased excretion of 2-AAA, tryptophan, and kynurenine.
Authors
- Jane F. Ferguson (ORCID: https://orcid.org/0000-0001-6896-1025)
- Stacy Desine (ORCID: https://orcid.org/0000-0003-3268-7380)
- Amanda C. Doran
- E. Danielle Dean
- Holly M. Smith
- M. Wade Calcutt
- Jonathan D. Mosley
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Endocrinology Diabetes & Metabolism
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1002/edm2.70168
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Vanderbilt University
- Vanderbilt Institute for Clinical and Translational Research
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences