Urine as a non-invasive alternative for HPV DNA detection: A comparative study with cervical swabs in Northeast India

This study assessed urine as a non-invasive alternative to cervical swabs for human papillomavirus (HPV) DNA detection using nested PCR in 350 paired samples from women across five Northeastern Indian states. HPV DNA was found in 27.4% of urine and 38.3% of cervical swabs, with 21.1% concordant positives. Urine identified 22 additional positives missed by swabs, while 60 were swab-only. Using cervical swabs as the reference, urine showed 55.2% sensitivity, 89.8% specificity, and moderate concordance (κ = 0.48). Despite modest sensitivity, urine sampling may serve as a feasible, culturally acceptable adjunct for HPV screening in under-screened populations.

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Publication Details

Journal
Indian Journal of Medical Microbiology
Published
2026-02-21
DOI
https://doi.org/10.1016/j.ijmmb.2026.101081
Primary Topic
Cervical Cancer and HPV Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Urine as a non-invasive alternative for HPV DNA detection: A comparative study with cervical swabs in Northeast India

Borkakoty Bj, Paresh Shyam, Pesona Grace Lucksom, Basumoti Apum et al.
Indian Journal of Medical Microbiology
Cervical Cancer and HPV Research
article

Urine as a non-invasive alternative for HPV DNA detection: A comparative study with cervical swabs in Northeast India

Borkakoty Bj, Paresh Shyam, Pesona Grace Lucksom, Basumoti Apum, Mousumi Dutta, Munmun Gohain, Jaharlal Baidya, Nargis K. Bali, Sobnom Gogoi, Tapan Mazumdar, Harpreet Kaur, Catherine Manguri
article en

Abstract

This study assessed urine as a non-invasive alternative to cervical swabs for human papillomavirus (HPV) DNA detection using nested PCR in 350 paired samples from women across five Northeastern Indian states. HPV DNA was found in 27.4% of urine and 38.3% of cervical swabs, with 21.1% concordant positives. Urine identified 22 additional positives missed by swabs, while 60 were swab-only. Using cervical swabs as the reference, urine showed 55.2% sensitivity, 89.8% specificity, and moderate concordance (κ = 0.48). Despite modest sensitivity, urine sampling may serve as a feasible, culturally acceptable adjunct for HPV screening in under-screened populations.

Indian Journal of Medical MicrobiologyVol. 60
Mizoram University (IN), Sher-i-Kashmir Institute of Medical Sciences (IN), Regional Medical Research Centre (IN), Regional Medical Research Center (IN), Indian Council of Philosophical Research (IN), Synod Hospital (IN), Regional Medical Research Centre (IN), Bapu Nature Cure Hospital & Yogashram (IN), Aizawl Adventist Hospital (IN), Agartala Government Medical College (IN), Sikkim Manipal University (IN), Assam Medical College (IN)
Openalex Percentile: Top 47%
Cervical Cancer and HPV Research
DOIOpen Access PDFOpenAlex
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