Three‐Year Follow‐Up of the PACI Randomized Controlled Trial (PACI‐ON): Effects of Early Intervention for Atopic Dermatitis on Atopic March
Early enhanced AD intervention was associated with a sustained modest reduction in its planned primary follow-up outcome of FA and safety (growth) up to age 3. Although most differences were small and may reflect early diagnosis and good overall management in both groups, the findings support early AD treatment as a potential strategy to modify allergic disease trajectories.
Authors
- Ryuhei Yasuoka
- Hiroyuki Wakiguchi (ORCID: https://orcid.org/0000-0003-1534-2583)
- Shunji Hasegawa (ORCID: https://orcid.org/0000-0002-1438-7993)
- Michihiro Kono (ORCID: https://orcid.org/0000-0003-2639-1583)
- Takaaki Itonaga (ORCID: https://orcid.org/0000-0003-3476-4175)
- Risa TAMAGAWA‐MINEOKA
- Shigenori Kabashima
- Kyongsun Pak (ORCID: https://orcid.org/0000-0002-0934-8949)
- Y. Kondo
- Amane Shigekawa
- T. Kobayashi (ORCID: https://orcid.org/0000-0002-3673-4052)
- Yoko Nezu
- Yusuke Inuzuka (ORCID: https://orcid.org/0000-0003-4808-1789)
- Hisako Ogasawara
- Katsuhito Iikura
- Mami Shimada (ORCID: https://orcid.org/0009-0007-9188-5906)
- Tatsuki Fukuie
- Koji Masuda (ORCID: https://orcid.org/0000-0001-7468-3762)
- Rei Kanai
- Masashi Akiyama (ORCID: https://orcid.org/0000-0001-5863-9315)
- Kunihiko Tsuchiya
- Hiroshi Kitazawa
- Hajime Hosoi
- Yukihiro Ohya
- M Morimoto
- Kiwako Yamamoto‐Hanada
- Masaki Futamura
- Miori Sato
- Norito Katoh
- Taiji Nakano
- Alexandre Xu
- M. Ebisawa
- Osamu Natsume
- Kenji Toyokuni
- Tomoki Yaguchi
- Sakura Sato
- Yuji Mori
- Hywel C. Williams
- Takao Fujisawa
- Fumi Ishikawa
- Mayako Saito‐Abe
- Kazumitsu Sugiura
- Hirohisa Saito
- Makoto Kameda
- Takahiro Kawaguchi
- Yuri Takaoka
Institutions
- Shizuoka University (JP)
- University of Nottingham (GB)
- Fujita Health University (JP)
- Chiba University (JP)
- Yamaguchi University (JP)
- Oita University (JP)
- Akita University (JP)
- Osaka Prefectural Medical Center (JP)
- Hamamatsu University School of Medicine (JP)
- Nagoya City University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Showa General Hospital (JP)
- National Sagamihara Hospital (JP)
- Fujita Health University Hospital (JP)
- National Center For Child Health and Development (JP)
- Saitama Municipal Hospital (JP)
- Tohoku Medical and Pharmaceutical University Hospital (JP)
- National Mie Hospital (JP)
- Nagoya Medical Center (JP)
- Nagoya University (JP)
- Tohoku Medical and Pharmaceutical University (JP)
- Kindai University (JP)
Publication Details
- Journal
- Allergy
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1111/all.70262
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00