Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more

The results establish powerful new models to discriminate sex-chromosome and gonadal hormone effects that cause sex differences in rat physiology and disease.

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Publication Details

Journal
Biology of Sex Differences
Published
2026-02-21
DOI
https://doi.org/10.1186/s13293-026-00837-5
Primary Topic
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Type
article
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article

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more

Dale R. Sengelaub, Tara Mohanroy, Shanie Landen, Michael N. Grzybowski et al.
Biology of Sex Differences
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
article

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more

Dale R. Sengelaub, Tara Mohanroy, Shanie Landen, Michael N. Grzybowski, Monika Tutaj, Lynn Malloy, Janelle Ryan, William Grisham, Ted Kalbfleisch, Vincent R. Harley, Arnold Ac, Helen Skaletsky, Akiko Takizawa, Jonathan Wanagat, Carrie Wiese, Xuqi Chen, Laurent Vergnes, Jeremy W. Prokop, O’Donnell Liza, Melinda R. Dwinell, Julia L. Ciosek, Aron M Geurts, Karen Reue, V. Andree Furlan, Helen R. Schmidtke, Kai Li, David C. Page
article en

Abstract

The results establish powerful new models to discriminate sex-chromosome and gonadal hormone effects that cause sex differences in rat physiology and disease.

Biology of Sex Differences
Griffith University (AU), Van Andel Institute (US), Children's National (US), Howard Hughes Medical Institute (US), University of Kentucky (US), University of California, Los Angeles (US), Medical College of Wisconsin (US), Monash Medical Centre (AU), Hudson Institute of Medical Research (AU), Indiana University Bloomington (US)
Gender equality
Openalex Percentile: Top 45%
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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