Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: four core genotypes and more
The results establish powerful new models to discriminate sex-chromosome and gonadal hormone effects that cause sex differences in rat physiology and disease.
Authors
- Dale R. Sengelaub (ORCID: https://orcid.org/0000-0002-6166-8632)
- Tara Mohanroy
- Shanie Landen (ORCID: https://orcid.org/0000-0002-7658-030X)
- Michael N. Grzybowski (ORCID: https://orcid.org/0000-0002-8115-2748)
- Monika Tutaj (ORCID: https://orcid.org/0000-0002-0378-4002)
- Lynn Malloy
- Janelle Ryan (ORCID: https://orcid.org/0009-0006-9813-1472)
- William Grisham (ORCID: https://orcid.org/0000-0003-1339-8399)
- Ted Kalbfleisch (ORCID: https://orcid.org/0000-0002-2370-8189)
- Vincent R. Harley (ORCID: https://orcid.org/0000-0002-2405-1262)
- Arnold Ac
- Helen Skaletsky (ORCID: https://orcid.org/0000-0002-2724-3673)
- Akiko Takizawa (ORCID: https://orcid.org/0000-0001-9101-5512)
- Jonathan Wanagat (ORCID: https://orcid.org/0000-0002-8460-8616)
- Carrie Wiese
- Xuqi Chen (ORCID: https://orcid.org/0000-0001-7668-9367)
- Laurent Vergnes (ORCID: https://orcid.org/0000-0002-8804-589X)
- Jeremy W. Prokop (ORCID: https://orcid.org/0000-0002-1818-9695)
- O’Donnell Liza
- Melinda R. Dwinell (ORCID: https://orcid.org/0000-0002-9528-3618)
- Julia L. Ciosek
- Aron M Geurts
- Karen Reue
- V. Andree Furlan
- Helen R. Schmidtke
- Kai Li
- David C. Page
Institutions
- Griffith University (AU)
- Van Andel Institute (US)
- Children's National (US)
- Howard Hughes Medical Institute (US)
- University of Kentucky (US)
- University of California, Los Angeles (US)
- Medical College of Wisconsin (US)
- Monash Medical Centre (AU)
- Hudson Institute of Medical Research (AU)
- Indiana University Bloomington (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1186/s13293-026-00837-5
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00