A target-guided drug repurposing strategy for antibacterial discovery
Our study revealed that the combination of 8 μg/ml lifitegrast and PMBN can effectively inhibit six gram-negative bacteria. Folate rescue experiments showed that the preliminary antibacterial mechanism of lifitegrast is to inhibit the function of FolA. In addition, future research should explore the structure-activity relationship of lifitegrast and its impact on antibacterial activity.
Authors
- Xiang Lian (ORCID: https://orcid.org/0000-0001-7681-3807)
- Anqiang Ye
- Haotian Li (ORCID: https://orcid.org/0000-0002-5720-8078)
- hongtu cui
- Dongdong Zhang
- Zhenshun Cheng
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1186/s12866-026-04710-8
- Primary Topic
- Biochemical and Structural Characterization
- Type
- article
- Field-Weighted Citation Impact
- 0.00