Effect of adjunctive perampanel on daytime sleepiness and quality of life in adults with focal–onset seizures: Post hoc analyses of the AMPA study
In the FAS, adjunctive perampanel did not worsen daytime sleepiness for ≤ 12 months. In a small subset of patients, seizure frequency was reduced, regardless of ESS changes, and mean QoL at EoT was improved for those without excessive daytime sleepiness but declined for those with excessive daytime sleepiness. No new safety signals emerged.
Authors
- Anna Patten (ORCID: https://orcid.org/0000-0003-0036-9732)
- Claudio Liguori (ORCID: https://orcid.org/0000-0003-2845-1332)
- Ricardo Sáinz-Fuertes
- Anna Lisa Gentile
- Martina Chiacchiaretta
- Giovanni Assenza
Institutions
- University of Rome Tor Vergata (IT)
- Università Campus Bio-Medico (IT)
- Campus Bio Medico University Hospital (IT)
- Eisai (United Kingdom) (GB)
- Eisai (Italy) (IT)
Publication Details
- Journal
- Epilepsy & Behavior
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1016/j.yebeh.2026.110962
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00