β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health

β-casomorphin-7 (βCM-7) is a bioactive peptide released after the digestion of β-casein A1 variant, mostly found in European cow breeds' milk. This review explores the occurrence, characteristics, identification, techno-functionality, and the potential health effects of βCM-7. It displays opioid-like properties because of its affinity for μ-opioid receptors, affecting both food texture and biological functions. βCM-7 has potential advantages on immune and gastrointestinal health; however, concerns persist regarding its adverse effects.

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Publication Details

Journal
npj Science of Food
Published
2026-02-21
DOI
https://doi.org/10.1038/s41538-026-00762-2
Primary Topic
Protein Hydrolysis and Bioactive Peptides
Type
article
Field-Weighted Citation Impact
0.00

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article

β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health

Shao‐Quan Liu, Gafar Babatunde Bamigbade, Mayssa Hachem, Zain Najjar et al.
npj Science of Food
Protein Hydrolysis and Bioactive Peptides
article

β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health

Shao‐Quan Liu, Gafar Babatunde Bamigbade, Mayssa Hachem, Zain Najjar, Abdelmoneim H. Ali, Mutamed Ayyash
article en

Abstract

β-casomorphin-7 (βCM-7) is a bioactive peptide released after the digestion of β-casein A1 variant, mostly found in European cow breeds' milk. This review explores the occurrence, characteristics, identification, techno-functionality, and the potential health effects of βCM-7. It displays opioid-like properties because of its affinity for μ-opioid receptors, affecting both food texture and biological functions. βCM-7 has potential advantages on immune and gastrointestinal health; however, concerns persist regarding its adverse effects.

npj Science of Food
National University of Singapore (SG), Khalifa University of Science and Technology (AE), United Arab Emirates University (AE)
United Arab Emirates University
Zero hunger
Openalex Percentile: Top 46%
Protein Hydrolysis and Bioactive Peptides
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β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health — Shao‐Quan Liu, Gafar Babatunde Bamigbade, et al. · npj Science of Food (2026) | TGRS Research Map | TGRS