Successful treatment of scalp Bowen's disease with 5-Aminolevulinic acid-photodynamic therapy combined with electric microneedling: A case report
This case report presents a 79-year-old male with scalp Bowen's disease and multiple comorbidities, precluding surgery. An innovative combination of nano-microneedle pretreatment and 5-Aminolevulinic Acid-Photodynamic Therapy (5-ALA-PDT) was utilized. Following five sessions, complete clinical clearance was achieved, maintained over 18 months of follow-up without recurrence. This synergistic approach enhances drug delivery and light efficacy, overcoming traditional PDT penetration limits. This successful non-surgical treatment for scalp BD using microneedle-assisted PDT, provides a novel therapeutic option for complex, inoperable cases, but rerquires further clinical validation.
Authors
- Tianhui Ye
- Na Zhang (ORCID: https://orcid.org/0000-0001-9510-4520)
- Jun Yao (ORCID: https://orcid.org/0000-0003-0275-4132)
- Gongjun Xu (ORCID: https://orcid.org/0000-0002-6045-6478)
- Wenbo Shi
- Chao Gao
- Lei Zeng
- Hongping Ge
Institutions
- Jinhua Academy of Agricultural Sciences (CN)
- Jinhua Central Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1016/j.pdpdt.2026.105404
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00