ROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata
We developed a biocompatible, ROS-responsive hydrogel platform for the local delivery of miR-665, which effectively attenuated inflammatory signaling and stimulated hair follicle regeneration in AA. This study provides a novel miRNA-biomaterial combination strategy that holds promise for targeted, durable, and safe treatment of AA.
Authors
- Xiaohai Zhu
- Y Li (ORCID: https://orcid.org/0009-0008-1882-1938)
- Qixiang Gui (ORCID: https://orcid.org/0009-0005-8590-1258)
- Zhiwan Liu
- Lie Zhu (ORCID: https://orcid.org/0000-0002-4947-9767)
- Wenjing TanTai
- Jie Xiang (ORCID: https://orcid.org/0000-0002-0080-0820)
- Luo Wt
- Minjuan Wu
- Jiansheng Zheng
- Zheyuan Hu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Second Military Medical University (CN)
- Zunyi Medical University (CN)
- Shanghai East Hospital (CN)
- 175th Hospital of People's Liberation Army (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1186/s12951-026-04214-7
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00