Clinical and transcriptomic risk factors for post-tuberculosis lung disease in a cohort of Kenyan adults
Despite common clinical risk factors (lower mid-upper arm circumference, radiographic lung involvement), PTLD phenotypes have unique transcriptional signatures. Restrictive-PTLD is marked by early pro-fibrotic inflammation. In contrast, obstructive-PTLD is characterized by persistent inflammation at treatment completion.
Authors
- T R Hawn
- Lilian N. Njagi (ORCID: https://orcid.org/0000-0002-5067-0788)
- Daniel J. Rittenhouse (ORCID: https://orcid.org/0009-0006-7198-7609)
- L Akeyo Kijaro
- Kristina Crothers (ORCID: https://orcid.org/0000-0001-9702-0371)
- F. Attia Engi
- Joy Githua (ORCID: https://orcid.org/0009-0007-3295-2275)
- Jay Kolls
- R Max Segnitz
- Mst Shamima Khatun S
- David J Horne
- Jerry S Zifodya
- Videlis Nduba
Institutions
- Tulane University (US)
- University of Washington (US)
- Kenya Medical Research Institute (KE)
- VA Puget Sound Health Care System (US)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1093/ajrccm/aamag063
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00