BMI-Related Genetic Factors and COPD Imaging Phenotypes

In individuals with and without COPD, a higher BMI polygenic risk is associated with both quantitative and visual decreased emphysema and increased AWT, suggesting genetic determinants of BMI affect both emphysema and airway wall thickening.

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Publication Details

Journal
Annals of the American Thoracic Society
Published
2026-02-21
DOI
https://doi.org/10.1093/annalsats/aaoag007
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
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article

BMI-Related Genetic Factors and COPD Imaging Phenotypes

B Hobbs, Catherine L. Debban, Stephen M. Humphries, Heena Rijhwani et al.
Annals of the American Thoracic Society
Chronic Obstructive Pulmonary Disease (COPD) Research
article

BMI-Related Genetic Factors and COPD Imaging Phenotypes

B Hobbs, Catherine L. Debban, Stephen M. Humphries, Heena Rijhwani, George R Washko, Celli BR, F. La Rosa, Jingzhou Zhang, Michael H Cho, Per Bakke, Alvar Agustí, R Graham Barr, Elizabeth C Oelsner, Edwin K Silverman, Josée Dupuis, Matthew Moll, David A Lynch, Ani W Manichaikul, Guy G Bruselle
article en

Abstract

In individuals with and without COPD, a higher BMI polygenic risk is associated with both quantitative and visual decreased emphysema and increased AWT, suggesting genetic determinants of BMI affect both emphysema and airway wall thickening.

Annals of the American Thoracic Society
Boston University (US), Brigham and Women's Hospital (US), Toshiba (Japan) (JP), Columbia University Irving Medical Center (US), University of Virginia Health System (US), Ghent University Hospital (BE), VA Boston Healthcare System (US), McGill University Health Centre (CA), Barcelona Biomedical Research Park (ES), National Jewish Health (US), Hospital Clínic de Barcelona (ES), Framingham Heart Study (US), University of Bergen (NO), McGill University (CA), University of Virginia (US), Universitat de Barcelona (ES), University of Colorado Denver (US)
Openalex Percentile: Top 47%
Chronic Obstructive Pulmonary Disease (COPD) Research
DOISourceOpenAlex
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