Paeoniflorin protects against radiation enteritis by suppressing YY1/ACSL4 axis to attenuate murine intestinal epithelial injury and ferroptosis

PF alleviated IR-induced damage and ferroptosis of IEC-6 cells by targeting the YY1/ACSL4 axis, providing a novel mechanistic basis for its application in RE treatment.

Authors

Institutions

Publication Details

Journal
Immunobiology
Published
2026-02-21
DOI
https://doi.org/10.1016/j.imbio.2026.153167
Primary Topic
Effects of Radiation Exposure
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Paeoniflorin protects against radiation enteritis by suppressing YY1/ACSL4 axis to attenuate murine intestinal epithelial injury and ferroptosis

Haoyu Ren, Jiao Yu, Yang Zhang, Qing Wang et al.
Immunobiology
Effects of Radiation Exposure
article

Paeoniflorin protects against radiation enteritis by suppressing YY1/ACSL4 axis to attenuate murine intestinal epithelial injury and ferroptosis

Haoyu Ren, Jiao Yu, Yang Zhang, Qing Wang, Lei An, Yuyan Guo
article en

Abstract

PF alleviated IR-induced damage and ferroptosis of IEC-6 cells by targeting the YY1/ACSL4 axis, providing a novel mechanistic basis for its application in RE treatment.

ImmunobiologyVol. 231(2)
Shanxi Medical University (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Shanxi Provincial People’s Hospital (CN)
Openalex Percentile: Top 48%
Effects of Radiation Exposure
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.