Base‐Mediated One‐Pot Efficient Synthesis of Fully Substituted 4‐Sulfinyl 1,2,3‐Triazoles From Esters

Here an efficient method for the synthesis of fully substituted 4‐sulfinyl‐1,2,3‐triazoles has been developed using readily available aryl esters, sulfoxides, and azides under mild conditions in a one pot. This approach proceeds through a β‐keto sulfoxide intermediate, facilitated by lithium nitride (Li 3 N) and sodium tert‐butoxide ( t ‐BuONa), to afford 1,4,5‐trisubstituted‐1,2,3‐triazoles in moderate to good yields with high regioselectivity. The reaction demonstrates broad substrate scope, good functional‐group tolerance, inexpensive reagents, and mild reaction conditions. This method provides a simple and efficient protocol for accessing sulfinyl triazoles.