Trimetazidine is associated with suppression of endoplasmic reticulum stress-mediated NLRP3 inflammasome activation in type 1 diabetes-induced liver damage in rats
These results demonstrate a hepatoprotective role for TMZ in T1D-induced liver injury, potentially mediated through suppression of ER stress, inflammation, and caspase-1-dependent pyroptosis.
Authors
- Eman A. E. Farrag
- Maha O. Hammad (ORCID: https://orcid.org/0000-0002-7136-4499)
- Sally M. Safwat
- Zeinab Shouman (ORCID: https://orcid.org/0000-0002-2138-028X)
- Marwa Abd El-kader
Institutions
- Mansoura University (EG)
- Al Baha University (SA)
- Delta University for Science and Technology (EG)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1186/s40001-026-03949-1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00