Stem cells from human exfoliated deciduous teeth secretome hydrogel combined with α-mangostin for periodontal bone regeneration: In vivo study
The combination of hydrogel SHED secretome α-mangostin effectively modulates the inflammatory environment by reducing TNF-α level and enhancing IL-10 production, thereby promoting the expression of the osteogenic factor BMP-2. This finding suggests an effective strategy for periodontal bone regeneration processes.
Authors
- Hendrik Setia Budi (ORCID: https://orcid.org/0000-0002-5518-3372)
- Huda Rashad Qaid (ORCID: https://orcid.org/0000-0001-9392-0241)
- Farouk Al-ghazaly
- Rubbig Diferly Mahendra
- Rini Devijanti Ridwan
- Chanaya Miranda Riveira
- Mohammed Ahmed Aljunaid
- Osamah Mohammed Al-Kawri
- Yuliati
- Ananda Firman Putranto
- Abumabdian Nasar Aqrabi
Institutions
- Universitas Airlangga (ID)
- Taiz University (YE)
- Al-Saeeda University (YE)
Publication Details
- Journal
- Journal of Oral Biology and Craniofacial Research
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1016/j.jobcr.2026.101425
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00