It's a Gas: Bioconjugation With Vapor‐Phase Reagents

Bioconjugation is a large field with many diverse goals, needs, and challenges, that requires a broad toolbox of fundamentally different synthetic approaches. As an emerging class of bioconjugation reagents, gas molecules bring new reactivity and selectivity concepts. Beyond these fundamental questions, gas-phase reagents may have unique advantages, such as access to porous material and structures, and diffusions/penetration differences in reaction in complex tissues or other contexts. This concept article examines vapor-phase reagents, as well as their reactivity and selectivity, for the modification of natural peptides and proteins.