A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain (Adv. Funct. Mater. 15/2026)
3D Breast Cancer Models Metastasized breast tumor cells to the brain interact with the brain extracellular matrix proteins (background image; red circle lower left) and with neurons via pseudosynaptic contacts and with astrocytes via gap junctions (circles upper right). The neuronal firing capacity is increased in the presence of tumor cells (circle, upper left). More information can be found in the Research Article by Carmen Villmann and co-workers (10.1002/adfm.202515220).
Authors
- Mateo S. Andrade Mier (ORCID: https://orcid.org/0009-0003-5153-0693)
- Gregor Lang (ORCID: https://orcid.org/0000-0001-9819-8630)
- Mike Friedrich
- Reiner Strick (ORCID: https://orcid.org/0000-0002-8141-7099)
- Christian Stigloher (ORCID: https://orcid.org/0000-0001-6941-2669)
- Zan Lamberger (ORCID: https://orcid.org/0000-0002-9814-5173)
- Katrin G. Heinze (ORCID: https://orcid.org/0000-0003-2372-6800)
- Jessica Faber (ORCID: https://orcid.org/0000-0001-8372-495X)
- Carmen Villmann (ORCID: https://orcid.org/0000-0003-1498-6950)
- Esra Türker (ORCID: https://orcid.org/0000-0002-9328-5513)
- Silvia Budday (ORCID: https://orcid.org/0000-0002-7072-8174)
- Nicoletta Murenu (ORCID: https://orcid.org/0009-0003-0905-2288)
- Pamela L. Strissel
- J. Weigelt
- Jörg Tessmar
- Natascha Schaefer
- Antje Appelt‐Menzel
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Würzburg (DE)
- Universitätsklinikum Erlangen (DE)
- Universitätsklinikum Würzburg (DE)
- Bavarian Polymer Institute (DE)
- Fraunhofer Institute for Silicate Research (DE)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/adfm.74287
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00