Sex-specific hypothalamic PVN transcriptomic signatures of blood pressure autonomic regulation and neuroinflammation in hypertension
These results provide new insights into the cardiovascular and molecular basis of sex differences in hypertension, suggesting distinct neurohumoral autonomic profile in males, whereas in females a greater anti-inflammatory component. These findings offer a valuable framework for developing future sex-specific therapeutic strategies.
Authors
- Murphy D.M.
- Lozić M.
- Pauža A.G.
- Japundžić-Žigon N.Z.
- Mecawi A.S.
- Šarenac O.
- Nani J.V.
- Jovanovic M.
- Duque V.J.
Institutions
- University of Auckland (NZ)
- AbbVie (United States) (US)
- University of Bristol (GB)
- University of Belgrade (RS)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1186/s13293-026-00855-3
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00