Leveraging MCP and Corrective RAG for Scalable and Interoperable Multi-Agent Healthcare Systems

The rapid evolution of Generative AI (GenAI) has created the conditions for developing innovative solutions that disrupt all fields of human-related activities. Within the healthcare sector, numerous AI-driven applications have emerged, offering comprehensive health-related insights and addressing user questions in real time. Nevertheless, most of them use general-purpose Large Language Models (LLMs); consequently, the responses may not be as accurate as required in clinical settings. Therefore, the research community is adopting efficient architectures, such as Multi-Agent Systems (MAS) to optimize task allocation, reasoning processes, and system scalability. Most recently, the Model Context Protocol (MCP) has been introduced; however, very few applications apply this protocol within a healthcare MAS. Furthermore, Retrieval-Augmented Generation (RAG) has proven essential for grounding AI responses in verified clinical literature. This paper proposes a novel architecture that integrates these technologies to create an advanced Agentic Corrective RAG (CRAG) system. Unlike standard approaches, this method incorporates an active evaluation layer that autonomously detects retrieval failures and triggers corrective fallback mechanisms to ensure safety and accuracy. A comparative analysis was conducted for this architecture against Typical RAG and Cache-Augmented Generation (CAG), demonstrating that the proposed solution improves workflow efficiency and enables more accurate, context-aware interventions in healthcare.

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Publication Details

Journal
Electronics
Published
2026-02-21
DOI
https://doi.org/10.3390/electronics15040888
Primary Topic
Machine Learning in Healthcare
Type
article
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article

Leveraging MCP and Corrective RAG for Scalable and Interoperable Multi-Agent Healthcare Systems

Panayiotis Tsanakas, Andreas Menychtas, Dimitrios Kalathas, Ilias Maglogiannis
Electronics
Machine Learning in Healthcare
article

Leveraging MCP and Corrective RAG for Scalable and Interoperable Multi-Agent Healthcare Systems

Panayiotis Tsanakas, Andreas Menychtas, Dimitrios Kalathas, Ilias Maglogiannis
article en

Abstract

The rapid evolution of Generative AI (GenAI) has created the conditions for developing innovative solutions that disrupt all fields of human-related activities. Within the healthcare sector, numerous AI-driven applications have emerged, offering comprehensive health-related insights and addressing user questions in real time. Nevertheless, most of them use general-purpose Large Language Models (LLMs); consequently, the responses may not be as accurate as required in clinical settings. Therefore, the research community is adopting efficient architectures, such as Multi-Agent Systems (MAS) to optimize task allocation, reasoning processes, and system scalability. Most recently, the Model Context Protocol (MCP) has been introduced; however, very few applications apply this protocol within a healthcare MAS. Furthermore, Retrieval-Augmented Generation (RAG) has proven essential for grounding AI responses in verified clinical literature. This paper proposes a novel architecture that integrates these technologies to create an advanced Agentic Corrective RAG (CRAG) system. Unlike standard approaches, this method incorporates an active evaluation layer that autonomously detects retrieval failures and triggers corrective fallback mechanisms to ensure safety and accuracy. A comparative analysis was conducted for this architecture against Typical RAG and Cache-Augmented Generation (CAG), demonstrating that the proposed solution improves workflow efficiency and enables more accurate, context-aware interventions in healthcare.

ElectronicsVol. 15(4)
University of Piraeus (GR), National Technical University of Athens (GR)
Industry, innovation and infrastructure
Openalex Percentile: Top 51%
Machine Learning in Healthcare
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Leveraging MCP and Corrective RAG for Scalable and Interoperable Multi-Agent Healthcare Systems — Panayiotis Tsanakas, Andreas Menychtas, et al. · Electronics (2026) | TGRS Research Map | TGRS