Distinct associations between body mass index and polyunsaturated fatty acids in dementia with Lewy Bodies and Alzheimer’s disease
BMI in DLB patients was positively associated with elevated downstream omega-6 metabolites and desaturase and elongase activity, compatible with higher fatty‑acid turnover and systemic inflammatory state hypothesized in DLB. These findings highlight the distinct metabolic alterations across dementia subtypes that are relevant for personalized nutritional strategies in dementia care.
Authors
- Miguel Germán Borda (ORCID: https://orcid.org/0000-0001-5832-0603)
- Alberto Jaramillo-Jiménez (ORCID: https://orcid.org/0000-0001-5374-6410)
- Nicolás Castellanos-Perilla (ORCID: https://orcid.org/0000-0002-8229-2611)
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- George Barretto
- Audun Osland Vik-M
- Rolf K Berge
- Diego Alejandro Tovar-Rios
- Dag Aarsland
Institutions
- University of Limerick (IE)
- Stavanger University Hospital (NO)
- Universidad de Antioquia (CO)
- National University Health System (SG)
- University of Bergen (NO)
- Universidad del Valle (CO)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1016/j.jnha.2026.100810
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00