Uremic Toxin-Driven Vascular Calcification in Chronic Kidney Disease: Molecular Pathways and Integrated Phenotypes
This phenotype-oriented paradigm transforms VC from an inevitable complication into a targetable and potentially reversible manifestation of uremic toxicity, establishing a translational foundation for precision-based vascular medicine in chronic kidney disease. The framework enables biomarker-guided patient stratification, rational therapeutic selection, and phenotype-enriched clinical trial design.
Authors
- Paola Ciceri (ORCID: https://orcid.org/0009-0001-6090-578X)
- Maria Teresa Sciarrone Alibrandi (ORCID: https://orcid.org/0000-0001-6322-0818)
- Lorenza Magagnoli (ORCID: https://orcid.org/0000-0003-2853-1332)
- Nadia Edvige Foligno (ORCID: https://orcid.org/0000-0001-9536-9254)
- Rodolfo Rivera (ORCID: https://orcid.org/0000-0002-5456-6785)
- Mario Cozzolino
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- CTO Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Toxins
- Published
- 2026-02-21
- DOI
- https://doi.org/10.3390/toxins18020112
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00