Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates
Our findings suggest that GBM-associated perivascular invasion disrupts glymphatic function, as evidenced by a significantly lower DTI-ALPS index in the tumor-affected hemisphere. The inverse correlation between the DTI-ALPS index and both volume and cellularity metrics highlights the extent to which GBM alters perivascular fluid dynamics.
Authors
- Hope M. Reecher (ORCID: https://orcid.org/0000-0001-5112-2401)
- Daniel J. Destiche
- Fitzgerald Kyereme
- Elaine J. Tanhehco
- Max Krucoff (ORCID: https://orcid.org/0000-0002-9577-8944)
- Biprojit Nath
- Bo H. Chao (ORCID: https://orcid.org/0000-0003-2335-5579)
- Aleksandra Winiarz (ORCID: https://orcid.org/0000-0002-6994-5796)
- Matthew J. Oborski
- Samuel Bobholz (ORCID: https://orcid.org/0000-0003-1525-7418)
- Savannah Duenweg (ORCID: https://orcid.org/0000-0003-4010-7737)
- Jamie Jacobsohn
- Allison K. Lowman (ORCID: https://orcid.org/0000-0002-2520-8145)
- Michael Barrett (ORCID: https://orcid.org/0000-0003-1775-8347)
- Daniel C. Kim
- Jennifer Connelly
- E. Kelly S. Mrachek
- Anjishnu Banerjee
- Mohit Agarwal
Institutions
- Medical College of Wisconsin (US)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1007/s11060-026-05458-x
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense