Exploring Myricetin's biological impact in hybrid compounds for enhanced bioactivities

Myricetin is a naturally occurring flavonoid that may be extracted from various plant sources. It has gained considerable attention owing to its extensive array of pharmacological properties, encompassing antioxidant, anti-inflammatory, anticancer, and neuroprotective activities. This manuscript is the first review so far that explored the bioactivity of myricetin-containing molecules during the period 2013–2025 to give a quick glance on the recent developed and optimized myricetin-hybrid chemical combinations, as well as their potential applications in the treatment of specific diseases. In this review, several compounds with notable pharmacological properties and biological activities were identified and emphasized for their unique structural features. For instance, the anticancer properties with an efficacy value of 0.9 μM presented by compound 4a were attributed to its chromene scaffold and furan moiety that were able to interact with the signaling pathways of the cancer cell. The antifungal activity with a value of 13.24 μg/mL was deconstrued by compound 5a due to its isoxazole substitution that can enhance cellular permeability and disrupt fungal cell membranes. A significant effect on the antibacterial activity with a value of 1.1 μg/mL was presented by compound 11b owing to its piperidine derivative, which was able to promote membrane penetration and inhibit metabolic processes. Lastly, a substantial antiviral activity with a value of 80.1 μg/mL introduced by compound 12e was notable due to its quinoline-thioether linkage that enhances interactions with viral proteins, disrupting replication cycles. Notably, the findings highlighted the effective bioactivity of these hybrids, suggesting promising avenues for therapeutic interventions and paving the way for future research in this area.