Interpretable Ensemble Machine Learning Prediction of Nonadherence and the Risk of Nonpersistence of Targeted Disease-Modifying Antirheumatic Agents in Older Adults With Rheumatoid Arthritis

We developed ML models predicting nonadherence and nonpersistence of b/tsDMARDs for older adults with RA. There is potential to leverage ML for understanding patients' behavior of utilizing b/tsDMARDs treatment with a goal towards personalized medicine in RA.

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Publication Details

Journal
Clinical Therapeutics
Published
2026-02-21
DOI
https://doi.org/10.1016/j.clinthera.2026.01.007
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
Field-Weighted Citation Impact
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article

Interpretable Ensemble Machine Learning Prediction of Nonadherence and the Risk of Nonpersistence of Targeted Disease-Modifying Antirheumatic Agents in Older Adults With Rheumatoid Arthritis

Yinan Huang, Sandeep Agarwal
Clinical Therapeutics
Rheumatoid Arthritis Research and Therapies
article

Interpretable Ensemble Machine Learning Prediction of Nonadherence and the Risk of Nonpersistence of Targeted Disease-Modifying Antirheumatic Agents in Older Adults With Rheumatoid Arthritis

Yinan Huang, Sandeep Agarwal
article en

Abstract

We developed ML models predicting nonadherence and nonpersistence of b/tsDMARDs for older adults with RA. There is potential to leverage ML for understanding patients' behavior of utilizing b/tsDMARDs treatment with a goal towards personalized medicine in RA.

Clinical TherapeuticsVol. 48(3)
Baylor College of Medicine (US), University of Mississippi (US)
Quality Education
Openalex Percentile: Top 49%
Rheumatoid Arthritis Research and Therapies
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