DNA methylation-mediated silencing of HNF1B promotes bladder cancer progression
Our study unveils a novel epigenetic mechanism in bladder cancer, whereby promoter hypermethylation silences HNF1B, thereby promoting tumor progression through activation of the MAPK pathway. These findings establishe HNF1B status as a potential biomarker for stratifying patients who may benefit from targeted therapies against this pathway.
Authors
- Yuanqing Dai
- Cong Luo (ORCID: https://orcid.org/0000-0002-0879-3127)
- Zhiyong Cai
- Jiao Hu (ORCID: https://orcid.org/0000-0003-4226-6416)
- Xiaogen Kuang
- Ping Liu
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1186/s13148-026-02079-z
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00