Extrafollicular Tph2–CD11c+CD21- B cell interactions orchestrate immune dysregulation in IgG4-related disease
This study identifies a novel Tph2-CD11c<sup>+</sup>CD21<sup>-</sup> B cell axis driving extrafollicular immune dysregulation in IgG4-RD. Tph2 cells link humoral activation with cytotoxicity, and CD11c<sup>+</sup>CD21<sup>-</sup> B cells serve as producers of IgG4 associated with disease severity. Targeting this axis may provide therapeutic strategies for refractory or relapsing IgG4-RD beyond glucocorticoids.
Authors
- Keisuke Yamamoto (ORCID: https://orcid.org/0000-0002-6323-9540)
- Makoto Kurose
- Ryoto Yajima
- Tsuyoshi Okuni
- Ryuta Kamekura (ORCID: https://orcid.org/0000-0002-9921-947X)
- Motohisa Yamamoto (ORCID: https://orcid.org/0000-0003-2742-2484)
- Shingo Ichimiya (ORCID: https://orcid.org/0000-0003-2874-774X)
- Hiroki Takahashi (ORCID: https://orcid.org/0000-0001-6791-936X)
- Kenichi Takano
- Akihisa Tanaka
- Hiroshi Sakamoto
- Shin Takayanagi
Institutions
- Sapporo Medical University (JP)
- University of Tokyo Hospital (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.alit.2026.01.005
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00