Accuracy of clinical diagnosis in neurodegenerative diseases - a study of 455 autopsy cases
Clinical diagnostic accuracy of neurodegenerative diseases varies, with sensitivity as the main limiting factor. Improving diagnostic sensitivity will be essential for early and accurate patient identification, especially as disease-modifying therapies targeting causal proteinopathies become available. Achieving this will depend on the development and clinical implementation of reliable molecular biomarkers that indicate the causal proteinopathies of neurodegenerative diseases.
Authors
- Jochen Herms (ORCID: https://orcid.org/0000-0002-6201-1042)
- Viktoria Ruf
- S. Roeber
- Adrian Danek
- Armin Giese
- Thomas Arzberger
- Johannes Levin
- Günter U. Höglinger
- Jonathan Vöglein
- Irena Ebner
Institutions
- General Motors (Germany) (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s00415-026-13680-w
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft