De-implementing inappropriate benzodiazepine prescribing in primary care: an overview of systematic reviews informed by behavioral frameworks

This overview demonstrates that multifaceted interventions-particularly those integrating patient education, audit-and-feedback, and pharmacist involvement-are the most effective for reducing inappropriate benzodiazepine use in primary care. Evidence also suggests that even brief, theory-informed interventions can achieve moderate effectiveness. Despite this progress, most studies lack explicit theoretical frameworks, underscoring the need for theory-driven approaches to enhance intervention design, implementation, and sustainability. Future research should focus on patient-centered strategies, long-term adherence, and broader representation from diverse socioeconomic settings. Registered in PROSPERO (CRD42024548653).