Clinical phenotype of 504 pustular psoriasis patients from Europe and Egypt: a multi-center observational study

Background: Pustular psoriasis (PP) comprises a group of rare autoinflammatory skin diseases characterized by sterile pustules. Previous studies have focused on Western or East-Asian cohorts, leaving North African populations underrepresented. Objectives: This study aimed to describe the demographic and clinical features of a large cohort of European and Egyptian PP patients. Methods: We collected data on 504 PP patients from 12 centers across five European countries and Egypt, analyzing their demographic profiles, clinical presentations, and treatment histories. Conclusions: This study highlights significant variations between European and Egyptian PP patients. Europeans presented more commonly with PPP, whereas Egyptian patients had more GPP and fewer coexisting PV diagnoses.