Allergic airway reactions rewired by PI3Kδ mutation
In this issue of JEM, Golec et al. (https://doi.org/10.1084/jem.20252154) report that a mutation of PI-3 kinase underlying activated PI3K δ syndrome (APDS) impairs type 2 immunity. Surprisingly, mice with this mutation have disordered responses to allergic insults, with enhanced production of IFN-γ and a decrease in Th2 cytokines.
Authors
- Larry Kane (ORCID: https://orcid.org/0000-0001-5198-516X)
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1084/jem.20252509
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00