Design, Synthesis, and Biological Evaluation of 1,3,4-Oxadiazole-oxazole-pyrimidine Derivativesas Anticancer Agents

A new series of 1,3,4-oxadiazole-oxazole-pyrimidine compounds (10a–10j) was synthesized and their structures were determined using 1H, 13C NMR and mass spectral data. Further, all compounds were examined for their preliminary anticancer properties towards four types of cancer cell lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by using of MTT method. The obtained IC50 values were compared with the known standard drug etoposide. The investigation of anticancer testing indicated that all derivatives displayed moderate to good anticancer activities. Among them, these compounds 10a, 10b, 10c, 10d, and 10g displayed more potent activity. Predominantly, one compound 10a showed superior activity.