Omeprazole is associated with voriconazole-associated hepatotoxicity: PPI-stratified analysis and a clinically actionable nomogram from an 848-patient cohort
Omeprazole co-administration was associated with higher VRC-associated hepatotoxicity, consistent with increased VRC exposure (C<sub>min</sub>). Omeprazole-specific C<sub>min</sub> thresholds (4.1 and 5.5 mg/L) support early TDM and PPI optimization when omeprazole is unavoidable.
Authors
- Huaijun Zhu
- Yuhang Ding
- Jinping Zhang
- Yanhong Meng
- Qiuhui Wu
Institutions
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1016/j.ijantimicag.2026.107749
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00