RCT: Omega‐3 fatty acids not supported as adjunct therapy for pediatric depression

A randomized clinical trial (RCT) of children and adolescents found that omega‐3 fatty acids such as EPA and DHA, as an adjunct to antidepressants, did not outperform placebo in youths with major depressive disorder (MDD).

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Publication Details

Journal
The Brown University Child & Adolescent Psychopharmacology Update
Published
2026-02-01
DOI
https://doi.org/10.1002/cpu.31037
Primary Topic
Fatty Acid Research and Health
Type
article
Field-Weighted Citation Impact
0.00
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article

RCT: Omega‐3 fatty acids not supported as adjunct therapy for pediatric depression

Alison Knopf
The Brown University Child & Adolescent Psychopharmacology Update
Fatty Acid Research and Health
article

RCT: Omega‐3 fatty acids not supported as adjunct therapy for pediatric depression

Alison Knopf
article en

Abstract

A randomized clinical trial (RCT) of children and adolescents found that omega‐3 fatty acids such as EPA and DHA, as an adjunct to antidepressants, did not outperform placebo in youths with major depressive disorder (MDD).

The Brown University Child & Adolescent Psychopharmacology UpdateVol. 28(2)
Good health and well-being
Openalex Percentile: Top 47%
Fatty Acid Research and Health
DOIOpen Access PDFOpenAlex
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RCT: Omega‐3 fatty acids not supported as adjunct therapy for pediatric depression — Alison Knopf · The Brown University Child & Adolescent Psychopharmacology Update (2026) | TGRS Research Map | TGRS