Emergence of a novel cefotaxime- and ciprofloxacin-resistant strain of serogroup Y Neisseria meningitidis sequence type 23 clonal complex in China
A novel cefotaxime- and ciprofloxacin-resistant MenY cc23 clone has emerged in China, with an enhanced transmissibility and a higher level of cefotaxime-resistance, potentially challenging the current IMD treatment and chemoprophylaxis strategies across broader geographic regions. Continuous surveillance for this dual-resistant clone is warranted, utilizing molecular markers including ST-18108, NEIS1753_5058 allele, and the 175 SNPs identified in this study.
Authors
- Ming Guang
- Meng Song (ORCID: https://orcid.org/0000-0003-3084-993X)
- Jiting Han
- Suxia Yao
- Panpan Lv
- Hui Wang
- Mingliang Chen
- Yang Wang
- Hongxia Yang
- Yue Jiang
Institutions
- Xian Center for Disease Control and Prevention (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Infection
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1016/j.jinf.2026.106713
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- University of Oxford
- European Commission
- National Natural Science Foundation of China