Abstract PS1-13-07: Exploring End-of-Life Preparedness Among Patients with Advanced Breast Cancer and Their Caregivers: A Dyadic Qualitative Study

Abstract Abstract Title: Exploring End-of-Life Preparedness Among Patients with Advanced Breast Cancer and Their Caregivers: A Dyadic Qualitative Study Background: Preparation for end-of-life (EOL) care is a critical yet often overlooked component of cancer care, particularly among patients with advanced breast cancer and their caregivers. Understanding how both members of the dyad conceptualize preparedness can inform culturally sensitive interventions that support emotional, practical, and relational needs in the terminal phase of illness. Objective: This study explores the experiences, perspectives, and perceived needs related to EOL preparedness among dyads of patients with stage III or IV breast cancer and their primary caregivers. Methods: A total of 30 participants, 15 patients diagnosed with stage III or IV breast cancer and 15 of their primary family caregivers, were recruited to participate in semi-structured, in-depth interviews. Using a dyadic and thematic approach, interviews explored participants’ definitions of preparedness, experiences with emotional and practical support, cultural beliefs, advance care planning, and caregiving burdens. Data were coded using a structured codebook and analyzed deductively to identify key themes across and within dyads. Results: Participants shared nuanced perspectives on emotional, spiritual, and informational readiness for EOL. While some patients expressed acceptance and clarity around their goals, others emphasized fear or avoidance. Caregivers often highlighted the emotional toll and uncertainty of supporting loved ones without adequate resources. Both patients and caregivers identified unmet needs in communication, access to culturally appropriate support, and financial guidance. A subset of dyads discussed advance directives and spiritual practices as sources of comfort or conflict. Preparation was described as an evolving process shaped by clinical events, relational dynamics, and cultural values. Conclusions: Preliminary findings suggest that EOL preparedness is a dynamic and multidimensional experience influenced by personal, interpersonal, and cultural factors. Dyadic approaches to research and intervention development are essential to addressing the interconnected realities of patients and caregivers facing advanced breast cancer. Further analysis will inform the development of targeted, culturally grounded interventions to improve EOL support in this population. Citation Format: L. Rosario, E. Castro, Z. Rodriguez, N. Torres. Exploring End-of-Life Preparedness Among Patients with Advanced Breast Cancer and Their Caregivers: A Dyadic Qualitative Study [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS1-13-07.