H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury
The study identifies an H3K18la-mediated SPHK1-SIRT1 axis as a key factor of RTEC pyroptosis in SA-AKI. The combined pharmacological strategy of NAD<sup>+</sup> supplementation and SPHK1 inhibition represents a promising therapeutic strategy for SA-AKI.
Authors
- Shengbo Han
- Yuhang Hu
- Wenfeng Zhuo
- Eryang Zhao
- Guozheng Lv
- Guangyu Zhao
- Rong Hu
- Yan Huang
- Gang Zhao
- Hongda Wang
- Zhu Zeng
- Yingsong Zhao
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-18
- DOI
- https://doi.org/10.7150/thno.122991
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00