Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts
Gut microbial diversity and 44 reproducible species are independently linked to kidney function in community-dwelling adults. Enrichment of histidine and carnitine pathways and their circulating metabolites implicates microbial metabolism as a contributor to eGFR variability, suggesting tractable targets for early kidney protection.
Authors
- Sergi Sayols-Baixeras (ORCID: https://orcid.org/0000-0002-1181-6262)
- Gabriel Baldanzi (ORCID: https://orcid.org/0000-0003-3962-3953)
- Aron C. Eklund (ORCID: https://orcid.org/0000-0003-0861-1001)
- G. Bergström
- T Fall
- Tessa Schillemans (ORCID: https://orcid.org/0000-0002-1044-1630)
- Lin Yi-Ting
- Jacob Bak Holm (ORCID: https://orcid.org/0000-0003-1756-0875)
- Koen F. Dekkers (ORCID: https://orcid.org/0000-0002-4074-7235)
- Jonas Wuopio (ORCID: https://orcid.org/0000-0001-5813-5926)
- Tíscar Graells (ORCID: https://orcid.org/0000-0002-2376-3559)
- Nynne Nielsen (ORCID: https://orcid.org/0009-0003-5603-3514)
- H.Bjørn Nielsen
- Marju Orho-Melander
- Gunnar Engström
- Johan Ärnlöv
- Andrei Malinovschi
- J.Gustav Smith
Institutions
- Dalarna University (SE)
- Uppsala University (SE)
- Kaohsiung Medical University (TW)
- Lund University (SE)
- University of Trento (IT)
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Karolinska Institutet (SE)
- Clinical Microbiomics (Denmark) (DK)
- Center for Clinical Research Dalarna (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Kidney International
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.kint.2026.01.021
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00