Diffuse Alveolar Hemorrhage in a Patient Receiving Temozolomide: A Suspected Drug-related Case Report and Brief Review of Literature

REPORTable to maintain SpO 2 above 80% on noninvasive ventilatory support.So, he was electively intubated and started on mechanical ventilation with prone positioning.Despite all measures, he was able to maintain a saturation of 91% at 100% fraction of inspired oxygen (FiO 2 ).His hemoglobin was 9.0 gm/dL, which was 14 gm/dL 15 days back.Platelets, total leukocyte count, differential leukocyte count, urine microscopy, urine albumin-to-creatinine ratio, and thyroid function tests were normal.Additional tests, including NT-proBNP (N-terminal prohormone of brain natriuretic peptide) level, complement C3 and C4 levels, and creatine phosphokinase, were within the normal range.Electrocardiogram (ECG) and echocardiography were normal.Antinuclear antibody (ANA) and antineutrophil cytoplasmic antibody (ANCA) were negative.