Pallidus internus versus subthalamic nucleus deep brain stimulation for Meige syndrome: a randomized, controlled, double-blind multicenter trial
GPi-DBS and STN-DBS demonstrate comparable safety and efficacy in patients with MeS. STN-DBS requires lower stimulation parameters than GPi-DBS. The optimal stimulation sites are the posterolateral dorsal GPi and the dorsal STN. Greater preoperative speech/swallowing impairment predicts poorer outcomes.
Authors
- Guolin Shi (ORCID: https://orcid.org/0000-0003-4404-725X)
- Xiao-Man Shi
- Botao Xiong (ORCID: https://orcid.org/0000-0001-7549-9246)
- Senlin Yin (ORCID: https://orcid.org/0000-0003-2241-3749)
- Yan Xu (ORCID: https://orcid.org/0000-0003-0379-8866)
- Ninghui Zhao (ORCID: https://orcid.org/0000-0002-1797-2071)
- Linglong Xiao
- Deng-hui Li
- Jiaming Li
- Mengdi Wang (ORCID: https://orcid.org/0000-0002-2101-9507)
- Wei Pan (ORCID: https://orcid.org/0000-0003-4518-2082)
- S. C. Hu (ORCID: https://orcid.org/0000-0003-2716-9888)
- Chenhao Yang
- Hao Deng
- Wei Wang
- Hao Feng
- Hai-Bo Ren
- Xiao-Wei Liu
- Yuan Gao
- Wei Zhang
- Li Jiang
- Yan Zhan
- Rui-Qing Yang
- Yang Wu
- Yu Cao
Institutions
- Hebrew University of Jerusalem (IL)
- Sichuan University (CN)
- Kunming Medical University (CN)
- West China Hospital of Sichuan University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Zigong First People's Hospital (CN)
- Nanchong Central Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2026-02-01
- DOI
- https://doi.org/10.3171/2025.9.jns251188
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00