Effects of extracorporeal membrane oxygenation on the pharmacokinetics and tissue penetration rates of vancomycin and linezolid: data from Landrace pigs
ECMO does not affect the pharmacokinetics of vancomycin or linezolid, suggesting that dose adjustments are unnecessary. Both drugs demonstrate wide tissue distribution during ECMO and are suitable treatment options in this setting.
Authors
- M X Chen
- Rong Liu (ORCID: https://orcid.org/0000-0002-3068-2984)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Ruilan Wang
- Yaxin Fan
- Tao Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1093/jac/dkag063
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00