Can Cord Blood Unit Selection Improve Outcomes After Single-Unit Unrelated Cord Blood Transplantation for Non-Remission Acute Myeloid Leukemia?

Among adults with non-remission AML undergoing single-unit CBT, CD34⁺ cell dose, CFU-GM count, and donor-recipient sex compatibility were independent predictors of survival and engraftment. Furthermore, the degree of HLA mismatch exhibited a complex relationship with relapse and NRM, highlighting the need for balanced graft selection strategies that optimize both engraftment and disease control in CBT for non-remission AML.

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Publication Details

Journal
Transplantation and Cellular Therapy
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jtct.2026.02.050
Citations
1
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
35.41
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article

Can Cord Blood Unit Selection Improve Outcomes After Single-Unit Unrelated Cord Blood Transplantation for Non-Remission Acute Myeloid Leukemia?

Junya Kanda, Takuro Kuriyama, Kazuto Ogura, Yasufumi Uehara et al.
1 citations
Transplantation and Cellular Therapy
Hematopoietic Stem Cell Transplantation
35.41
article

Can Cord Blood Unit Selection Improve Outcomes After Single-Unit Unrelated Cord Blood Transplantation for Non-Remission Acute Myeloid Leukemia?

Junya Kanda, Takuro Kuriyama, Kazuto Ogura, Yasufumi Uehara, Atsushi Wake, Norimichi Hattori, Toru Izumi, Yasuji Kozai, Fumihiko Ishimaru, Satoru Takada, Masatsugu Tanaka, Masamitsu Yanada, Marie Ohbiki, Yuta Katayama, Yoshiko Atsuta, Masahito Tokunaga, Koji Kawamura, Tadakazu Kondo, Naoyuki Uchida, Yoshimitsu Shimomura, Satoshi Yamasaki, Takaaki Konuma, Satoshi Takahashi
article en
1 citations

Abstract

Among adults with non-remission AML undergoing single-unit CBT, CD34⁺ cell dose, CFU-GM count, and donor-recipient sex compatibility were independent predictors of survival and engraftment. Furthermore, the degree of HLA mismatch exhibited a complex relationship with relapse and NRM, highlighting the need for balanced graft selection strategies that optimize both engraftment and disease control in CBT for non-remission AML.

Transplantation and Cellular Therapy
SHOWA Medical University (JP), Tokyo Medical University (JP), Kyoto University (JP), Japanese Red Cross Society, Japan (JP), Kanagawa Prefectural Hospital Organization (JP), Nagoya City University (JP), St Mary's Hospital (JP), Hamanomachi Hospital (JP), Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital (JP), Sendai Medical Center (JP), Tottori University Hospital (JP), Kitakyushu Municipal Medical Center (JP), Imamura Hospital (JP), Gunma Saiseikai Maebashi Hospital (JP), National Hospital Organization (JP), Tokyo Metropolitan Institute of Gerontology (JP), Tokyo Metropolitan Tama Medical Center (JP), The Japanese Data Center for Hematopoietic Cell Transplantation (JP), Kobe City Medical Center General Hospital (JP), Toranomon Hospital (JP), Kanagawa Cancer Center, The University of Tokyo (JP)
Openalex Percentile: Top 1%
Hematopoietic Stem Cell Transplantation
35.41
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